Blar i forfatter "Olsen, Lotte"

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    • Exploring and Targeting Novel Cancer Networks in Multidrug Resistant Neuroblastoma 

      Olsen, Lotte (Doctoral thesis; Doktorgradsavhandling, 2020-06-19)
      High-risk neuroblastoma has an overall survival of only 50%, and alternative treatment options for this patient group are needed. In this thesis, I will present novel insight into potential anti-tumor mechanisms for high-risk neuroblastoma. Firstly, our investigations have revealed a tumor suppressor function of the microRNA (miRNA) <i>miR-323a-3p</i> in neuroblastoma cells, and that this miRNA ...

    • Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells 

      Bhavsar, Swapnil; Olsen, Lotte; Løkke, Cecilie; Koster, Jan; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
      Background: Studies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a region commonly deleted in cancers, are associated with poor clinical outcome in the childhood cancer neuroblastoma. We have previously identified miR-323a-3p from this region to be downregulated in ...

    • Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma 

      Hald, Øyvind Holsbø; Olsen, Lotte; Gallo-Oller, Gabriel; Elfman, Lotta Helena Maria; Løkke, Cecilie; Kogner, Per; Sveinbjørnsson, Baldur; Flægstad, Trond; Johnsen, John Inge; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-12)
      Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...